胆汁酸代谢及其异常Bile acid metabolism and its abnormity一、胆汁的组成(composition of bile) 胆汁是由肝细胞将胆汁酸、无机离子和水分等分泌到胆小管所形成。 Bile from the liver cells to bile acids, inorganic ions such as water and released into the tube formed by bile canaliculi .1bile pigment cholesterolinorganic salt2To promote digestion and absorption of fat 促进脂肪的消化和吸收 To promote the absorption of fat-soluble vitamins 促进脂溶性维生素的吸收Regulation of cholesterol metabolism, The maintenance of cholesterol in the bile of the state of dissolution 调节胆固醇代谢, 维持胆汁中胆固醇的溶解状态二、胆汁( 主要是胆汁酸) 的功能Functon of bile acid 3Reduce oil/water surface tension 降低油/ 水两相之间的界面张力Make the hydrophobic lipids in aqueous micro-emulsion into a small micelle使疏水性的脂类在水相中乳化成细小的微团立体构象: 亲水面- 疏水面（较强的乳化剂）4原料(precursor) ：胆固醇(cholesterol )部位(site) ： 肝细胞(liver)种类(type) ： 游离型、结合型三、胆汁酸的代谢与功能 Metabolism and function of bile acids （一）初级胆汁酸的生物合成 Biosynthesis of primarybile acids概念（concept)胆固醇在肝细胞内转化生成的胆汁酸。Cholesterol in the liver cells generated into bile acids5胆酸 cholic acid鹅脱氧胆酸 chenodeoxy cholic acid游离型甘氨胆酸glycocholic acid牛磺胆酸 taurocholic acid甘氨鹅脱氧胆酸glycochenodeoxycholic acid牛磺鹅脱氧胆酸taurochenodeoxycholic acid结合型67部位(site): 小肠(small intestine) 大肠(large intestine) （二）次级胆汁酸的生物合成Biosynthesis second bile acid初级胆汁酸分泌到肠道后受肠道细菌作用生成的产物。 Primary bile acid secretion by the intestinal bacterial role in post-generated product概念（concept) ：8973127312771733122110111213胆汁酸本身的负反馈调节 Bile acid is a negative feedback regulation甲状腺激素可促进胆汁酸合成 Thyroid hormone may promote bile acid synthesis（三）合成过...
